Wolves have made nine changes from the team that were knocked out of the Carabao Cup by Ipswich in midweek.
Jose Sa is back in goal in place of Daniel Bentley, while Craig Dawson and Max Kilman come in for Jonny and Santiago Bueno in defence.
Ruben Semedo and Rayan Ait-Nouri start at wing-back in place of Matt Doherty and Hugo Bueno, and Mario Lemina and Joao Gomes replace Boubacar Traore and Tommy Doyle in midfield.
In attack, Pedro Neto and Matheus Cunha take the places of Pablo Sarabia and Sasa Kalajdzic.
Man City team news
Team to play Wolves: Ederson; Walker, Dias, Akanji, Ake; Nunes, Kovacic; Foden, Alvarez, Doku; Haaland.
Subs: Ortega, Carson, Phillips, Grealish, Gomez, Gvardiol, Bobb, Lewis.
Wolves team news
Team to play Man City: Sa; Dawson, Kilman, Toti; Semedo, Lemina, Gomes, Ait-Nouri; Neto, Cunha, Hwang.
Subs: Bentley, Doherty, S. Bueno, Traore, Silva, Kalajdzic, Jonny, Sarabia, Hodge.