Tottenham have made three changes from the humbling defeat at Newcastle two weeks ago.
One of the changes was enforced with Ben Davies replacing the injured Destiny Udogie at left-back, with the Italian out for the rest of the season.
Pierre-Emile Hojbjerg and Dejan Kulusevski also come into the starting line-up as Yves Bissouma and Brennan Johnson drop to the bench, which includes Richarlison with the striker back from a knee injury.
Mikel Arteta has stuck with the same Arsenal team that thrashed Chelsea in midweek.
This game comes too soon for Jurrien Timber, who does not make the bench.
Arsenal do have plenty of options to bring on though, with Jorginho, Gabriel Martinelli, Gabriel Jesus, Emile Smith Rowe and Eddie Nketiah among the substitutes.
Tottenham team news
Team to play Arsenal: Vicario; Porro, Romero, Van de Ven, Davies; Hojbjerg, Bentancur; Kulusevski, Maddison, Werner; Son.
Subs: Austin, Dragusin, Royal, Sarr, Bissouma, Lo Celso, Gil, Johnson, Richarlison.
Arsenal team news
Team to play Tottenham: Raya; White, Saliba, Gabriel, Tomiyasu; Partey, Rice, Odegaard; Saka, Havertz, Trossard.
Subs: Ramsdale, Kiwior, Zinchenko, Jorginho, Smith Rowe, Vieira, Martinelli, Jesus, Nketiah.