Tottenham will hope to maintain their unbeaten record with Antonio Conte opting to make five changes from his side’s 1-1 draw against West Ham in midweek.
Summer signing Richarlison makes his first start for Spurs with Cristian Romero, Rodrigo Bentancur and Ryan Sessegnon also stepping in.
France defender Clement Lenglet, on loan from Barcelona, also makes his second appearance.
Spurs XI: Lloris, Romero, Bentancur, Lenglet, Dier, Sessegnon, Emerson, Hojbjerg, Richarlison, Son, Kane
Subs: Forster, Doherty, Skipp, Sanchez, Perisic, Kulusevski, Tanganga, Davies, Bissouma
Marco Silva makes no changes to his Fulham side that beat Brighton 2-1 on Tuesday, when Alexander Mitrovic scored his 100th goal for the club.