Antonio Conte makes one change to his Tottenham team from their 2-1 win over Fulham at the weekend.
He has opted for Champions League experience at left wing-back with Ivan Perisic replacing Ryan Sessegnon.
Tottenham XI: Lloris, Royal Emerson, Romero, Dier, Lenglet, Perisic, Bentancur, Hojbjerg, Richarlison, Son, Kane.
Subs: Forster, Doherty, Spence, Tangana, Sanchez, Davies, Sessegnon, Skipp, Sarr, Bissouma, Bryan, Kulusevski.
Marseille, who are currently second in France’s Ligue 1 on goal difference, have made four changes from their 2-0 win over Auxerre at the weekend.
Manchester United loanee Eric Bailly and Samuel Gigot come in, as do Arsenal loanee Nuno Tavares and former Gunners midfielder Matteo Guendouzi.
Manchester City loanee Issa Kabore, Leonardo Balerdi, former Arsenal man Sead Kolasinac and ex-Leicester loanee Cengiz Under drop out.
Marseille XI: Lopez, Mbemba, Bailly, Gigot, Clauss, Tavares, Veretout, Rongier, Gerson, Guendouzi, Suarez.
Subs: Ngapandouentnbu, Blanco, Balerdi, Payet, Under, Gueye, Kolasinac, Kabore, Harit.