Roy Hodgson makes just one change from their 0-0 draw with Fulham as Jean-Philippe Mateta starts as the lone forward in place of Odsonne Edouard, who misses out with a hamstring issue.
Erik ten Hag makes four changes from their last Premier League win over Burnley, handing starts to Sofyan Amrabat, Raphael Varane, Mason Mount and Facundo Pellistri.
New signing Amrabat played in a hybrid left-back role in the first half of the midweek Carabao Cup meeting and looks to be operating from there again.
Mount played 45 minutes in that encounter and is deemed fit enough to start again following hamstring trouble.
Manchester United team news
Team to play Crystal Palace: Onana, Dalot, Lindelof, Varane, Amrabat, Casemiro, Mount, Fernandes, Rashford, Hojlund, Pellistri
Subs: Bayindir, Maguire, Martial, Eriksen, Garnacho, Evans, McTominay, Van de Beek, Hannibal
Crystal Palace team news
Team to play Manchester United: Johnstone, Ward, Guehi, Andersen, Mitchell, Doucoure, Hughes, Ayew, Eze, Schlupp, Mateta
Subs: Matthews, Holding, Clyne, Ebiowei, Richards, Riedewald, Rak-Sakyi, Ozoh, Ola-Adebomi