Sheffield United became the first team to be officially relegated from the Premier League this season.
This follows the Blades’ 5-1 defeat at Newcastle United on Saturday.
Chris Wilder’s side are 10 points from safety with just three games left following their 25th league defeat of a dismal season.
The bottom of the table Blades, who have only three league victories this term, will return to the Championship just 12 months after winning promotion.
Anel Ahmedhodzic put Sheffield ahead at St James’ Park, but Alexander Isak struck twice.
Bruno Guimaraes and Callum Wilson each netted and Ben Osborn scored an own goal to complete the rout.