Manchester United will face Granada in the quarter-final of the Europa League, while Arsenal will take on Slavia Prague.
United beat Serie A giants AC Milan in the last round with a 2-1 aggregate win.
Arsenal, meanwhile, survived a scare to beat Olympiacos 3-2 on aggregate to book their place in the final eight.
The other two ties are Ajax vs Roma and Dinamo Zagreb vs Villarreal.
The first-leg matches will be played on Thursday April 8, 2021.
The second legs are scheduled for Thursday April 15, 2021.
Full fixtures:
Granada vs Manchester United
Dinamo Zagreb vs Villarreal
Arsenal vs Slavia Prague
Ajax vs Roma