Ange Postecoglou makes two changes for his first Premier League home match as Spurs boss.
Emerson Royal, a goal scorer last week at Brentford, drops to the bench with Pedro Porro coming in at right-back. Oliver Skipp also comes out of the team, with Pape Sarr coming in.
James Maddison will again look to supply the chances after his two assists in west London.
Man Utd team news
Team to play Tottenham: Onana, Wan-Bissaka, Varane, Martinez, Shaw, Casemiro, Antony, Fernandes, Mount, Garnacho, Rashford.
Subs: Henderson, Vitek, Lindelof, Martial, Eriksen, Dalot, Sancho, Pellistri, McTominay.
Tottenham team news
Team to play Man Utd: Vicario, Porro, Romero, Van de Ven, Udogie, Sarr, Bissouma, Kulusevski, Maddison, Son, Richarlison.
Subs: Forster, Skipp, Hojbjerg, Sanchez, Royal, Perisic, Lo Celso, Solomon, Davies.