Manchester United manager, Erik ten Hag, has made five changes from the team that lost 1-0 at home to Real Sociedad last week.
The Dutchman has selected Martínez and Varane as his centre-back pairing. He has brought McTominay back in for Casemiro.
Bruno Fernandes has also come in for Fred, while Sancho replaces Elanga.
Additionally, Cristiano Ronaldo – who has been struggling for goals – leads the line for the Red Devils this evening.
Manchester United starting XI: De Gea, Dalot, Varane, Martinez, Malacia, McTominay, Eriksen, Fernandes, Antony, Ronaldo, Sancho.
Substitutes: Heaton, Vitek, Lindelof, Maguire, Shaw, Casemiro, Fred, Iqbal, Elanga, Garnacho, McNeill.