Arsenal have made eight changes from the team who lost 1-0 at Aston Villa on Saturday.
Only William Saliba, Gabriel and Kai Havertz keep their places in the team, as Mikel Arteta shuffles the pack.
The likes of Cedric Soares and Mohamed Elneny make their first starts of the season, while there is a Champions League debut for Aaron Ramsdale in goal.
The likes of Declan Rice, Bukayo Saka and Gabriel Jesus are on the bench, along with the returning Emile Smith Rowe from injury, plus youngster Reuell Walters, Lino Sousa and Ethan Nwaneri.
PSV team news
Team to play Arsenal: Benitez; Teze, Ramalho, Obispo, Mauro, Van Aanholt, Tillman, Saibari, Bakayoko, Pepi, Vertessen.
Subs: Drommel, Waterman, Sambo, Dest, Boscagli, Oppegard, Til, Babadi, De Jong.
Arsenal team to play PSV: Ramsdale; Cedric, Saliba, Gabriel, Kiwior; Jorginho, Elneny, Havertz; Trossard, Nketiah, Nelson.
Subs: Raya, Hein, White, Walters, Zinchenko, Sousa, Rice, Nwaneri, Smith Rowe, Odegaard, Saka, Jesus.