Manchester United have made one change from the side that lost to Nottingham Forest with Rasmus Hojlund replacing Antony, who is on the bench.
Casemiro and Lisandro Martinez are among the substitutes on their return from injury.
Christian Eriksen starts after recovering from illness during the week.
Timo Werner is set to make his Tottenham debut after joining on loan from RB Leipzig last week.
The forward goes straight into the starting line-up while fellow new signing Radu Dragusin is named on the bench.
Micky van de Ven also starts having not played since early November because of a hamstring injury.
Cristian Romero will line-up next to him having also recovered from injury despite manager Ange Postecoglou saying today’s game would be too soon for him.
Tottenham team news
Tottenham: Vicario, Porro, Skipp, Romero, Udogie, van de Ven, Bentancur, Hojbjerg, Johnson, Richarlison, Werner.
Subs: Dragusin, Gil Salvatierra, Emerson, Forster, Austin, Alonso, Donley, Dorrington.
Man Utd team news
Man Utd: Onana, Wan-Bissaka, Varane, Evans, Dalot, Eriksen, Mainoo, Garnacho, Bruno Fernandes, Rashford, Hojlund.
Subs: Bayindir, Martinez, Casemiro, Antony, Heaton, Pellistri, McTominay, Kambwala, Forson.