Manchester United manager Erik ten Hag names exactly the same starting XI from the 7-0 Premier League humbling at Liverpool last Sunday.
Man Utd XI: De Gea, Dalot, Varane, Martinez, Shaw, Casemiro, Fred, Antony, Fernandes, Rashford, Weghorst.
Subs: Heaton, Butland, Lindelof, Maguire, Malacia, Sancho, Pellistri, Wan Bissaka, Elanga, McTominay, Garnacho, Mainoo.
Real Betis make four changes to the side that drew against Real Madrid in La Liga last Sunday. Joaquin comes in to captain the side, while Juanmi, Luiz Henrique and Abner Vinicius also start.
Real Betis: Bravo, Sabaly, Pezzella, Felipe, Vinicius, Carvalho, Rodriguez, Henrique, Joaquin, Juanmi, Perez.
Subs: Gonzalez, Ruiz, Iglesias, Canales, Willian Jose, Rui Silva, Guardado, Ruibal, Martin, Sanchez, Miranda, Guerrero.