Luton boss Rob Edwards has understandably stuck with the team that drew 1-1 with Liverpool last weekend.
Teden Mengi, the Man Utd academy product, starts on his return to Old Trafford to face his boyhood club.
Tahith Chong, another former Man Utd youth product, is on the bench.
Raphael Varane has been left out of the Man Utd starting line-up for a fifth straight game.
Erik ten Hag prefers to bring in Victor Lindelof at centre-back after Jonny Evans was injured against FC Copenhagen on Wednesday.
Ten Hag’s only other change is at left-back with Sergio Reguilon coming back into the team.
Diogo Dalot retains his place, returning to right-back while Aaron Wan-Bissaka is not even in the squad.
Marcus Rashford’s suspension does not carry over to the Premier League so he starts for his 250th Premier League appearance.
Man Utd team news
Man Utd: Onana; Dalot, Maguire, Lindelof, Reguilon; McTominay, Eriksen, Fernandes; Rashford, Hojlund, Garnacho.
Subs: Bayindir, Amrabat, Mount, Martial, Varane, Antony, Pellistri, Mainoo, Hannibal.
Luton team news
Luton: Kaminski; Mengi, Lockyer, Osho; Kabore, Nakamba, Barkley, Doughty; Townsend, Morris, Ogbene.
Subs: Krul, Berry, Adebayo, Chong, Mpanzu, Clark, Brown, Giles, Nelson.