Marcus Rashford returns to the Manchester United side after missing the 1-0 win at Fulham with a training-ground knock.
The England forward replaces Antony in the only change to the XI that started the match at Craven Cottage.
Centre-back Victor Lindelof is also fit again but starts on the bench, with boss Erik ten Hag preferring to stick with Jonny Evans and Harry Maguire in the middle of defence.
Copenhagen team news
Team to play Man Utd: Grabara; Ankersen, Vavro, Diks, Jelert; Lerager, Falk, Goncalves; Elyounoussi, Claesson, Achouri.
Subs: Sander, Dithmer, Sorensen, Tanlongo, Larsson, Babacar, Oskarsson, Boilesen, Lund, O. Hojlund, Bardghji, Froholdt.
Man Utd team news
Team to play Copenhagen: Onana; Wan-Bissaka, Maguire, Evans, Dalot; McTominay, Eriksen; Garnacho, Fernandes, Rashford; Hojlund.
Subs: Bayindir, Heaton, Lindelof, Reguilon, Varane, Amrabat, Forson, Hannibal, Mount, Pellistri, Antony, Martial.