Captain Reece James returns, with Marc Cucurella moving to left-back and Levi Colwill dropping to the bench.
Thiago Silva is also among the subs, with Benoit Badiashile starting.
Conor Gallagher is back from suspension and comes in for Raheem Sterling, meaning Cole Palmer moves to the right wing.
Nicolas Jackson has also been left out, with Armando Broja taking his place in attack.
Christopher Nkunku and Romeo Lavia are still not fit for inclusion and continue to wait for their Chelsea debuts.
Everton have made just one change to the team that swept aside Newcastle in midweek.
James Garner returns from illness to take his place in midfield. Seamus Coleman drops out of the squad after picking up an injury against the Magpies.
Ashley Young returns to right-back, Jack Harrison moves to the right wing and Abdoulaye Doucoure will play off Dominic Calvert-Lewin.
Chelsea team news
Team to play Everton: Sanchez; James, Disasi, Badiashile, Cucurella; Caicedo, Fernandez; Palmer, Gallagher, Mudryk; Broja.
Subs:Petrovic, Silva, Sterling, Jackson, Colwill, Maatsen, Gilchrist, Matos, Castledine.
Everton team news
Team to play Chelsea: Pickford; Young, Tarkowski, Branthwaite, Mykolenko; Harrison, Garner, Gueye, McNeil; Doucoure; Calvert-Lewin.
Subs:Virginia, Patterson, Onana, Danjuma, Beto, Godfrey, Chermiti, Hunt, Dobbin.