Real Madrid coach Carlo Ancelotti decides to go for more solidity as Spain defender Nacho starts in place of Brazil forward Rodrygo.
That is the only change from Ancelotti’s team which drew 2-2 at La Liga rivals Valencia on Sunday.
England’s Jude Bellingham could play in a more advanced position, while Brahim Diaz – the matchwinner in the first leg – has to settle for a place on the bench.
Striker Joselu, who was doubtful with an ankle injury, is also a substitute. Keeper Thibaut Courtois, along with defenders David Alaba and Eder Militao, remain long-term absentees with knee injuries.
Real Madrid XI: Lunin, Carvajal, Nacho, Rudiger, Mendy, Valverde, Tchouameni, Kroos, Bellingham, Camavinga, Vinicius Jr.
Visitors RB Leipzig make two changes as they aim to overturn their first-leg deficit.
Belgium striker Loïs Openda will lead the line after coming off the bench in Saturday’s Bundesliga win at Bochum, while defensive midfielder Xaver Schlager returns after serving a domestic suspension.
RB Leipzig XI: Gulacsi, Henrichs, Orban, Castello, Raum, Simons, Haidara, Schlager, Olmo, Sesko, Openda.