Manchester City manager, Pep Guardiola, makes three changes to the side that began the 1-1 draw against Aston Villa in the Premier League at the weekend.
John Stones and Kyle Walker are both out with minor injuries.
Ilkay Gundogan drops to the bench. In come new signing Manuel Akanji, Sergio Gomez and Jack Grealish.
Man City XI: Ederson, Joao Cancelo, Akanji, Dias, Gomez, De Bruyne, Rodri, Bernardo Silva, Foden, Haaland, Grealish.
Subs: Phillips, Ake, Gundogan, Ortega, Alvarez, Mahrez, Carson, Palmer, Lewis, Wilson-Esbrand.
Sevilla boss Julen Lopetegui makes five changes to the side that started the 3-0 La Liga defeat against Barcelona at the weekend.
Erik Lamela misses out altogether while Gonzalo Montiel, Joan Jordan, Youssef En-Nesyri and Fernando drop to the bench.
That means on-loan Manchester United defender Alex Telles starts along with former City winger Jesus Navas, Thomas Delaney, Alejandro Gomez and Jose Angel Carmona.
Sevilla XI: Bounou, Carmona, Gudelj, Kouassi, Alex Telles, Jesus Navas, Rakitic, Delaney, Acuna, Isco, Gomez.
Subs: Dmitrovic, Montiel, Rekik, Dolberg, Suso, Jordan, Januzaj, Mir, En-Nesyri, Fernando, Salas, Flores.