New Chelsea manager, Graham Potter, has made three changes from the side that lost last time out in the Champions League.
This is the first time he will be taking charge of an official fixture.
Marc Cucurella comes in Ben Chilwell, with Thiago Silva and Jorginho also returning to the XI.
Wesley Fofana and Kalidou Koulibaly drop to the bench.
Chelsea: Kepa, James, Azpilicueta, Silva, Cucurella, Mount, Kovacic, Jorginho, Sterling, Aubameyang, Havertz.
Red Bull Salzburg have never beaten an English side in European competition in six attempts (drew one, lost five). Since drawing against Blackburn in the Uefa Cup back in September 2006, they have lost all five of their meetings with English opposition.
Chelsea have only lost one of their past 20 home games in the group stage of the Champions League (won 13, drew six).