Erik ten Hag makes four changes to the team that beat Aston Villa with Aaron Wan-Bissaka, Fred, Antony and Anthony Martial coming in. Out go Tyrell Malacia, Christian Eriksen, Jadon Sancho and Marcel Sabitzer.
Brighton also make four changes. No Pascal Gross or Joel Veltman in the squad, with Solly March and Deniz Undav dropping to the bench.
That means there are recalls for Kaoru Mitoma, Alexis Mac Allister and Moises Caicedo as well as an opportunity for teenager Facundo Buonanotte.
Brighton team news
Brighton team to play Man Utd: Steele, Webster, Dunk, Estupinan, Enciso, Caicedo, Gilmour, Mac Allister, Mitoma, Buonanotte, Welbeck.
Subs: Sanchez, Colwill, March, Undav, Ayari, Van Hecke, Offiah, Moran, Peupion.
Man Utd team news
Man Utd team to play Brighton: De Gea, Wan-Bissaka, Lindelof, Shaw, Dalot, Casemiro, Fred, Antony, Fernandes, Rashford, Martial.
Subs: Butland, Maguire, Malacia, Williams, Eriksen, Sabitzer, Sancho, Pellistri, Weghorst.