Arsenal have brought in Leandro Trossard from the start to replace the injured Gabriel Martinelli on the left wing.
Bukayo Saka is fit enough to start on the other side.
Aaron Ramsdale makes his first start since November, standing in for first-choice goalkeeper David Raya, who is ineligible against his parent club.
Oleksandr Zinchenko is also fit enough for a place on the bench after recovering from injury.
Brentford have made just one change with Keane Lewis-Potter replacing the absent Sergio Reguilon.
The on-loan left-back is missing from the matchday squad.
Arsenal team news
Arsenal team to play Brentford: Ramsdale, White, Saliba, Gabriel, Kiwior, Rice, Jorginho, Odegaard, Saka, Trossard, Havertz.
Brentford team news
Brentford team to play Arsenal: Flekken, Roerslev, Zanka, Ajer, Collins, Lewis-Potter, Norgaard, Onyeka, Janelt, Wissa, Toney.