Wolves manager Gary O’Neil is dealing with a lengthy injury list and has made four changes following Saturday’s 2-2 draw against Nottingham Forest.
Matheus Cunha, Pablo Sarabia and Nelson Semedo are out of the squad, while Mario Lemina drops to the bench.
Young winger Tawanda Chirewa makes his first league start with Hugo Bueno, Boubacar Traore and Hwang Hee-Chan also coming in.
O’Neil has named 15-year-old Wesley Okoduwa on a very youthful looking bench.
Wolves XI: Sa, S Bueno, Kilman, H Bueno, Toti, Traore, J Gomes, Doherty, Hwang, Doyle, Chirewa.
Subs: Bentley, Ait-Nouri, Lemina, Sarabia, Holman, Barnett, Ojinnaka, Okoduwa, Fraser.
Arsenal fell to a 2-0 loss when hosting Aston Villa in their last Premier League outing on Sunday and Mikel Arteta makes just one change.
Jakub Kiwior starts a game for the first time since 31 March as he is preferred to Oleksandr Zinchenko at left-back.
Arsenal XI: Raya, White, Saliba, Gabriel, Kiwior, Odegaard, Rice, Havertz, Saka, Jesus, Trossard.
Subs: Ramsdale, Partey, Smith Rowe, Martinelli, Nketiah, Jorginho, Vieira, Nelson, Zinchenko.