Wigan top scorer Stephen Humphrys, who missed the 1-1 draw at Barnsley, starts in one of two changes, replacing Josh Magennis, while Thelo Aasgaard comes in for Callum Lang.
Sub keeper Ben Amos is a former Manchester United player and James Carragher is the son of ex-England defender Jamie.
Wigan XI: Tickle, Sessegnon, Morrison, Hughes, Clarke, Adeeko, Shaw, Jones, Aasgaard, Godo, Humphrys.
Subs: Amos, Smith, Kerr, Carragher, Robinson, Wyke, McManaman, Lang, Magennis.
Manchester United make only two changes from the side that began the 2-1 loss to Nottingham Forest on 30 December.
Goalkeeper Andre Onana, who will be with Cameroon in the Africa Cup of Nations later this month, starts and the changes see Scott McTominay and Rasmus Hojlund come in for Christian Eriksen and Antony, while it is a youthful bench for United.
Manchester United XI: Onana, Dalot, Evans, Varane, Wan-Bissaka, McTominay, Mainoo, Garnacho, Fernandes, Hojlund, Rashford.
Subs: Bayindir, Heaton, Kambwala, Bennett, Pellistri, Forson, Shoretire, Hugill, Mejbri.