Timo Werner starts in place of Brennan Johnson in the only Tottenham change from their 3-0 defeat at Fulham before the international break.
Johnson is joined on the Spurs bench by Micky van de Ven, who has recovered from the hamstring injury sustained in the 4-0 win at Aston Villa earlier this month.
Tottenham XI: Vicario, Porro, Romero, Dragusin, Udogie, Bissouma, Sarr, Kulusevski, Maddison, Werner, Son.
Subs: Austin, Hojbjerg, Richarlison, Emerson, Lo Celso, Johnson, Bentancur, Davies, Van de Ven.
Rob Edwards makes two alterations to the Luton team that drew 1-1 with Nottingham Forest a fortnight ago.
Andros Townsend and Luke Berry come in, replacing Jordan Clark and the injured Chiedozie Ogbene.
Luton Town XI: Kaminski, Burke, Mengi, Kabore, Berry, Mpanzu, Barkley, Doughty, Townsend, Chong, Morris.
Subs: Shea, Krul, Woodrow, Clark, Hashioka, Onyedinma, Johnson, Nelson, Piesold.