Timo Werner starts for Tottenham in place of forward Richarlison, who has been ruled out for a month with a knee injury.
Spurs are boosted by the return of Destiny Udogie, however. He has missed the past three games with a knee issue but is fit enough to start with Ben Davies dropping to the bench.
Rodrigo Bentancur also starts in the third change the Spurs last match – a 1-0 defeat by Wolves.
Tottenham XI: Vicario (GK), Royal, Van de Ven, Romero, Udogie, Bissouma, Bentancur, Maddison, Son, Werner, Kulusevski
Substitutes: Austin (GK), Skipp, Højbjerg, Dragusin, Lo Celso, Johnson, Sarr, Davies, Scarlett
Crystal Palace manager Oliver Glasner makes just one change to the side that beat Burnley in his first game in charge and it’s a big one.
Eberechi Eze is fit enough to play for the first time since January. he replaces Odsonne Edouard in the starting XI.
Crystal Palace XI: Johnstone (GK), Ward, Andersen, Richards, Munoz, Wharton, Lerma, Mitchell, Ayew, Eze, Mateta.
Substitutes: Henderson (GK), Tomkins, Franca, Clyne, Hughes, Edouard, Ahamada, Plange, Ozoh