Gareth Southgate has made six changes to his England side that laboured to a 2-0 win over Malta on Friday.
Most notably, Harry Kane is benched and Ollie Watkins starts up front instead.
Rico Lewis makes his England debut at left-back while Kyle Walker captains the team from right-back.
Declan Rice returns to midfield alongside Trent Alexander-Arnold and Phil Foden.
Bukayo Saka comes in on the right and so too does Jack Grealish on the other side.
Kieran Tripper, Fikayo Tomori, Jordan Henderson and Conor Gallagher drop to the bench.
England team news – Watkins, Lewis start
England: Pickford; Walker, Guehi, Maguire, Lewis; Rice, Alexander-Arnold, Foden; Saka, Watkins, Grealish.
Subs: Tomori, Johnstone, Henderson, Phillips, Gallagher, Konsa, Rashford, Palmer, Kane, Ramsdale.
North Macedonia team news
North Macedonia: Dimitrievski, Manev, Serafimov, Musliu, Dimoski, Bardhi, Atanasov, Alimi, Alioski, Miovski, Elmas.
Subs: Kostadinov, Askovski, Iljazovski, Elezi, Churlinov, Mitrovski, Milan Ristovski, Todoroski, Aleksovski, Daci, Ademi, Siskovski.
