Manchester City make six changes to the side that beat Huddersfield 5-0 in the FA Cup last weekend.
Ederson is back in goal in place of Stefan Ortega, while Kyle Walker comes in for the injured Manuel Akanji at right-back and Nathan Ake replaces Sergio Gomez.
Meanwhile, Rodri, Bernardo Silva and Jeremy Doku replace Oscar Bobb, Rico Lewis and Jack Grealish.
Kevin de Bruyne continues his comeback from injury with a place on the bench.
Newcastle’s only change from the win at Sunderland in the FA Cup last weekend is enforced, with Joelinton’s injury ruling him out for the foreseeable future.
In comes 17-year-old Lewis Miley for the Brazilian in midfield, leaving the hosts’ bench even more stretched than normal.
Ben Parkinson, only promoted to the U21s in March, makes a Premier League bench for the fifth time this season, though Tino Livramento is absent from the squad with illness.
Man City team news
Team to face Newcastle: Ederson, Walker, Dias, Ake, Gvardiol, Rodrigo, Kovacic, Bernardo, Foden, Doku, Alvarez
Subs: Ortega Moreno, Phillips, Grealish, De Bruyne, Gomez, Nunes, Bobb, Susoho, Lewis.
Newcastle team news
Team to play Man City: Dubravka, Trippier, Schar, Botman, Burn, Guimaraes, Longstaff, Miley, Almiron, Gordon, Isak.
Subs: Karius, Gillespie, Dummett, Lascelles, Ritchie, Krafth, Hall, A Murphy, Parkinson.