West Ham have made two changes from the side that drew at home to Bournemouth last time out, with the headline being Kalvin Phillips dropping to the bench after a difficult debut.
Konstantinos Mavropanos also drops out, with David Moyes recalling Nayef Aguerd and Vladimir Coufal.
There could be a change in shape for the Hammers, who name five defenders and no striker. Mohammed Kudus and Jarrod Bowen look set to lead the attack.
Man Utd team news
Team to play West Ham: Onana, Dalot, Maguire, Martinez, Shaw, Casemiro, Mainoo, Fernandes, Garnacho, Hojlund, Rashford.
Subs: Bayindir, Lindelof, Amrabat, Varane, Eriksen, Forson, Antony, Diallo, McTominay.
West Ham team news
Team to play Man Utd: Areola; Coufal, Johnson, Zouma, Aguerd, Emerson; Soucek, Ward-Prowse, Alvarez; Kudus, Bowen.
Subs: Fabianski, Cresswell, Phillips, Mavropanos, Cornet, Ings, Ogbonna, Mubama, Scarles.