Rasmus Hojlund is fit to lead the line and Erik ten Hag has made an attacking change from the Everton game because he is effectively in for Casemiro.
Harry Maguire and Mason Mount are among the substitutes.
Mohamed Salah was on the bench against Manchester City last weekend but he is in the starting line-up for this one, with Andy Robertson also in at left-back for Liverpool.
Man Utd team news
Team to play Liverpool: Onana, Wan-Bissaka, Dalot, Varane, Lindelof, Mainoo, McTominay, Garnacho, Fernandes, Rashford, Hojlund.
Subs: Heaton, Kambwala, Maguire, Amad, Amrabat, Eriksen, Forson, Mount, Antony.
Liverpool team news
Team to play Man Utd: Kelleher, Gomez, Quansah, Van Dijk, Robertson, Endo, Szoboszlai, Mac Allister, Salah, Diaz, Nunez.
Subs: Adrian, Gakpo, Elliott, Tsimikas, Clark, McConnell, Gravenberch, Danns, Bradley.