Erik ten Hag makes one change from last week’s first leg in Barcelona. Tyrell Malacia drops to the bench, with Lisandro Martinez coming into the defence.
He keeps his place from the weekend victory against Leicester, as do David de Gea, Luke Shaw, Fred, Bruno Fernandez, Wout Weghorst and Marcus Rashford.
Barcelona make four changes from last Thursday’s draw. Marcos Alonso drops to the bench alongside Jordi Alba, while Gavi and Pedri miss out through injury.
Andreas Christensen, Alejandro Balde, Sergio Busquets and Sergi Roberto come into the XI.
Xavi has also named just nine substitutes this evening, compared to 11 last week.
Man Utd team news
Team to play Barcelona: De Gea, Wan-Bissaka, Varane, Martinez, Shaw, Casemiro, Fred, Fernandes, Weghorst, Sancho, Rashford.
Subs: Heaton, Lindelof, Maguire, Malacia, Sabitzer, Dalot, Antony, Pellistri, Elanga, McTominay, Garnacho, Mainoo.
Barcelona team news
Team to play Man Utd: Ter Stegen, Kounde, Araujo, Christensen, Balde, De Jong, Busquets, Kessie, Raphinha, Roberto, Lewandowski.
Subs: Pena, Tenas, Fati, Torres, Alonso, Alba, Garcia, Casado, Torre.