Eberechi Eze starts for Crystal Palace in an exciting front three alongside Jean-Philippe Mateta and Michael Olise.
Eze sat out of last weekend’s draw at Fulham while Palace captain Marc Guehi returns to make the bench after recovering from a knee problem which has sidelined him since early February.
Andre Ayew makes way for Eze and is on the bench.
Manchester United have made two changes from the side that drew with Burnley last time out, both of which are injury-enforced.
The main news is that Bruno Fernandes misses out, meaning Mason Mount is handed a rare start, while Jonny Evans returns to replace Harry Maguire in defence.
Scott McTominay, Anthony Martial and Marcus Rashford are all absent.
Man Utd team news
Man Utd: Onana, Wan-Bissaka, Casemiro, Evans, Dalot, Mainoo, Eriksen, Antony, Mount, Garnacho, Hojlund.
Subs: Bayindir, Heaton, Amrabat, Diallo, Collyer, Amass, Ogunneye, Jackson, Wheatley.
Crystal Palace team news
Crystal Palace: Henderson, Clyne, Andersen, Richards, Mitchell, Hughes, Wharton, Munoz, Eze, Olise, Mateta.
Subs: Matthews, Ward, Guehi, Ayew, Schlupp, Edouard, Ahamada, Riedewald, Rak-Sakyi.