Pep Guardiola has made four changes to the side that breezed past Burnley last Friday.
Summer signings Josko Gvardiol and Mateo Kovacic come in, as do Cole Palmer and Jack Grealish.
Kevin De Bruyne is absent with a hamstring injury, while Rico Lewis and Julian Alvarez drop to the bench.
Bernardo Silva is absent from the squad with illness.
Sevilla team news
Sevilla starting XI: Bounou, Navas, Bade, Gudelj, Acuna, Jordan, Rakitic, Oliver Torres, Ocampos, Lamela, En-Nesyri.
Subs: Dmitrovic, Gattoni, Pedrosa, Montiel, Suso, Rafa Mir, Corona, Sow, Gomez, Juanlu, Kike Salas, Bueno.
Man City team news
Man City starting XI: Ederson, Walker, Akanji, Gvardiol, Ake, Rodri, Kovacic, Foden, Palmer, Grealish, Haaland.
Subs: Ortega, Carson, Dias, Phillips, Stones, Laporte, Alvarez, Gomez, Perrone, Bobb, Lewis, McAtee.