Man City boss Pep Guardiola has made four changes from Saturday’s 1-1 draw with Liverpool in the Premier League.
Jack Grealish has recovered from illness to replace Jeremy Doku in the front three with Erling Haaland and Phil Foden.
Rico Lewis takes the places of Julian Alvarez and will sit in midfield alongside Rodri and Bernardo Silva.
Josko Gvardiol, signed from RB Leipzig in the summer, is preferred ahead of Nathan Ake against his old club. Kyle Walker, Ruben Dias and Manuel Akanji complete the back four.
Stefan Ortega has also been handed a start in goal with Ederson left on the bench.
Man City team news
Man City: Ortega; Walker, Akanji, Dias Gvardiol; Rodri, Lewis, Bernardo; Foden, Haaland, Grealish.
Subs: Ederson, Carson, Phillips, Stones, Ake, Doku, Alvarez, Gomez, Bobb.
RB Leipzig team news
RB Leipzig: Blaswich; Klostermann, Simakan, Lukeba, Raum; Haidara, X. Schlager, Seiwald; Forsberg, Openda, Simons.
Subs: Gulasci, Lenz, Pulsen, Baumgartner, Carvalho, Sesko, Henrichs, Kampl.