Kevin de Bruyne has returned to the Manchester City starting line-up in place of Phil Foden.
It is Pep Guardiola’s only change from their 1-0 win at Crystal Palace last Saturday.
Riyad Mahrez, who scored in the first leg, is also on the bench with Foden.
RB Leipzig team news
RB Leipzig: Blaswich, Orban, Haidara, Forsberg, Werner, Szoboszlai, Raum, Laimer, Gvardiol, Henrichs, Kampl.
Subs: Nyland, Nickisch, Simakan, Olmo, Poulsen, Klostermann, Silva, Halstenberg, Ba.
Man City team news
Man City: Ederson, Dias, Stones, Ake, Gundogan, Haaland, Grealish, Rodri, De Bruyne, Silva, Akanji.
Subs: Ortega, Carson, Walker, Phillips, Laporte, Alvarez, Gomez, Mahrez, Perrone, Foden, Palmer, Lewis.