Erling Haaland starts but Manchester City boss Pep Guardiola makes seven changes from the side that beat West Ham on Wednesday.
Ederson is back in goal, Aymeric Laporte, Rico Lewis and Manuel Akanji join Nathan Ake in defence, while Kevin de Bruyne is back from injury in midfield, with Ilkay Gundogan and Phil Foden also returning.
Man City XI: Ederson, Lewis, Akanji, Laporte, Ake, Gundogan, De Bruyne, Mahrez, Foden, Alvarez, Haaland
Subs: Ortega, Walker, Dias, Phillips, Stones, Grealish, Rodri, Silva, Gomez
New Leeds boss Sam Allardyce makes four changes from the team that lost 4-1 to Bournemouth in Javi Gracia’s final game in charge
Joel Robles replaces Ilian Meslier in goal, Junior Firpo and Max Wober come into defence and Adam Forshaw returns in midfield, with Robin Koch, Liam Cooper and Crysencio Summerville the other players making way.
Leeds XI: Robles, Kristensen, Wober, Firpo, Ayling, McKennie, Forshaw, Roca, Harrison, Bamford, Gnonto.
Subs: Meslier, Koch, Aaronson, Summerville, Rodrigo, Stuijk, Rutter, Greenwood, Gray