Manchester City boss Pep Guardiola makes four changes from the side who lost on penalties to Real Madrid in the Champions League on Wednesday.
The big news is that Erling Haaland is out of the squad completely with Julian Alvarez replacing him.
Stefan Ortega comes in for Ederson in goal while Nathan Ake and John Stones replace Ruben Dias and Josko Gvardiol in defence.
Manchester City XI: Ortega, Walker, Akanji, Ake, Stones, Rodri, Foden, De Bruyne, Bernardo Silva, Grealish, Alvarez.
Subs: Ederson, Dias, Kovacic, Doku, Gomez, Gvardiol, Nunes, Bobb, Lewis.
Chelsea make just one alteration after thrashing Everton 6-0 on Monday.
Enzo Fernandez returns in midfield with Mykhailo Mudryk dropping to the bench.
Chelsea XI: Petrovic, Gusto, Chalobah, Silva, Cucurella, Caicedo, Gallagher, Madueke, Palmer, Fernandez, Jackson.
Subs: Bettinelli, Badiashile, Disasi, Gilchrist, Chilwell, Chukwuemeka, Mudryk, Sterling, Washington.