Rob Edwards makes two changes from the home defeat to Sheffield United as two former Manchester United are given the chance to show their former employers what they missed out on.
Teden Mengi and Tahith Chong both start.
The big news for Manchester United is that Luke Shaw has been passed fit to play this afternoon.
Erik ten Hag has named an unchanged side from the 2-1 win over Aston Villa. Despite his goalscoring heroics off the bench last week, Scott McTominay has to settle for a spot on the bench.
Luton team news
Team to play Manchester United: Kaminski, Mengi, Osho, Bell, Doughty, Lokonga, Barkley, Ogbene, Chong, Morris, Adebayo
Subs: Krul, Berry, Woodrow, Kabore, Burke, Mpanzu, Clark, Townsend, Nelson
Man Utd team news
Team to play Luton: Onana; Dalot, Varane, Maguire, Shaw; Mainoo, Casemiro; Garnacho, Fernandes, Rashford; Hojlund
Substitutes: Bayindir, Evans, Lindelof, Diallo, Amrabat, Eriksen, Forson, McTominay, Antony