Mohamed Salah, Darwin Nunez and Dominik Szoboszlai are not included in the squad so it is another youthful Liverpool line-up.
There’s a senior debut for Lewis Koumas, son of Premier League midfielder Jason, for Liverpool in one of six changes made by Jurgen Klopp from the Carabao Cup final.
James McConnell, Bobby Clark and Jarrel Quansah start after their Wembley appearances, with Ibrahima Konate, Ryan Gravernerch and Wataru Endo sitting out.
Joe Gomez and Kostas Tsimikas start over Andy Robertson and Alexis Mac Allister, while Luis Diaz also sits this one out.
Southampton have also rung the changes – eight of them after their last Championship game on Saturday.
Only centre-backs Jack Stephens, Jan Bednarek and midfielder Joe Aribo keep their places.
Key players such as Kyle Walker-Peters, Che Adams and goalkeeper Gavin Bazunu are named on the bench.