Arsenal have made two changes from the side who beat Bournemouth 4-0 at the weekend.
Takehiro Tomiyasu and Leandro Trossard come into the team, with Ben White and Eddie Nketiah being rotated out .
That means Bukayo Saka starts despite picking up a knock on Saturday, with Thomas Partey on the bench as he steps up his return from injury.
David Raya continues in goal, while Arsenal’s bench does not include Gabriel Martinelli, who remains injured.
RC Lens team news
Team to face Arsenal: Samba, Gradit, Danso, Medina, Frankowski, Mendy, Abdul Samed, Machado, Sotoca, Wahi, Thomasson.
Subs: Leca, Pandor, Aguilar, Fulgini, Diouf, Maouassa, Said, El Aynaoui, Khusanov, Guilavogui.
Arsenal team news
Team to face RC Lens: Raya, Tomiyasu, Saliba, Gabriel, Zinchenko, Rice, Odegaard, Havertz, Saka, Jesus, Trossard.
Subs: Ramsdale, Hein, Partey, White, Smith Rowe, Nketiah, Kiwior, Cedric Soares, Jorginho, Vieira, Nelson, Elneny.