Chelsea have made five changes to the side that lost 2-0 at Everton last Sunday, with goalkeeper Djordje Petrovic coming in for his debut for the club in place of Robert Sanchez, who has a knee problem.
Meanwhile, Mauricio Pochettino also hands starts to the likes of Thiago Silva, Levi Colwill, Raheem Sterling and Nicolas Jackson.
And in a major boost for the Blues, Christopher Nkunku is named as a sub and could make his debut for the club after injuring his in preseason following his summer switch from RB Leipzig.
Chelsea team news
Team to play Sheff Utd: Petrovic, Disasi, Thiago Silva, Badiashile, Colwill, Caicedo, Gallagher, Sterling, Palmer, Mudryk, Jackson
Subs: Fernandez, Bettinelli, Nkunku, Broja, Gusto, Maatsen, Gilchrist, Bergstrom, Matos
Sheffield United team news
Team to play Chelsea: Foderingham, Bogle, Ahmedhodzic, Trusty, Lowe, Vinicius Souza, McAtee, Hamer, Brooks, Archer, McBurnie
Subs: Adam Davies, Baldock, Traore, Thomas, Norwood, Osborn, Ben Slimane, Larouci, Osula