Xavi makes three changes to the Barcelona side which beat Mallorca 1-0 in their weekend La Liga match.
This includes Robert Lewandowski coming into the XI, after the Polish striker was on the bench against Mallorca in preparation for this match.
Ronald Araujo and Fermin Lopez also come into the team.
Barcelona XI: Ter Stegen; Kounde, Cubarsi, Araujo, Cancelo; Lopez, Christensen, Gundogan; Yamal, Lewandowski, Raphinha.
Subs: Pena, Astralaga, Inigo Martinez, Joao Felix, Romeu, Roque, Sergi Roberto, Casado, Hernandez, Guiu, Fort.
There are two changes to the Napoli side which started their previous match, a 1-1 draw with Torino in Serie A.
Amir Rrahmani starts at centre-half, while Hamed Traore comes into midfield.
Victor Osimhen, as expected, leads the line.
Napoli XI: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Rui; Anguissa, Lobotka, Traore; Politano, Osimhen, Kvaratskhelia.
Subs: Contini, Gollini, Natan, Olivera, Simeone, Cajuste, Ngonge, Lindstrom, Mazzocchi, Ostigard, Raspadori.