Spurs have made two changes from the win over Everton, with Destiny Udogie replacing the injured Cristian Romero, meaning Emerson Royal shifts to centre-back.
Pierre-Emile Hojbjerg comes into the midfield for Oliver Skipp, who has a knock.
Richarlison has shaken off a knock of his own to keep his place up front.
Jason Steele returns in place of Bart Verbruggen as Roberto De Zerbi continues to heavily rotate his goalkeepers.
Danny Welbeck is in from the start having scored the equaliser against Crystal Palace as Baleba drops to the bench, where he is joined by Pervis Estupinan.
Adingra and Mitoma’s places in the starting XI are taken by Buonanotte and James Milner.
Brighton team news
Team to face Tottenham: Steele, Julio, Dunk, Milner, Van Hecke, Hinshelwood, Gilmour, Gross, Buonanotte, Joao Pedro, Welbeck.
Subs: Verbruggen, Dahoud, Lallana, Moder, Baleba, Ferguson, Estupinan, Baker-Boaitey, Barrington.
Tottenham team news
Team to play Brighton: Vicario; Porro, Royal, Davies, Udogie; Hojbjerg, Sarr; Johnson, Kulusevski, Son; Richarlison.
Subs: Forster, Dier, Dorrington, Phillips, Lo Celso, Santiago, Gil, Donley, Veliz.