Brentford have made two changes from the side that beat Tottenham. Mathias Jensen misses out completely, with Mikkel Damsgaard coming into the starting line-up.
Zanka also replaces Kevin Schade in the team, with Thomas Frank opting for a 3-5-2 against the champions.
Saman Ghoddos is named on the bench in his final home game for the Bees.
Erling Haaland is named on the bench and Kevin de Bruyne is left out completely as Manchester City have made eight changes from the side who drew 1-1 at Brighton.
Only Kyle Walker, Rico Lewis, Riyad Mahrez and Phil Foden keep their places in the team, with Pep Guardiola rotating ahead of next week’s FA Cup final.
That means Ederson returns in goal, Julian Alvarez returns up front with Cole Palmer, while Aymeric Laporte, Nathan Ake and Sergio Gomez come into the defence.
There’s also just a second Premier League for Kalvin Phillips in City colours.
Man City team news – Haaland on bench
Team to play Brentford: Ederson; Walker, Laporte, Ake, Gomez; Phillips, Lewis, Foden; Mahrez, Alvarez, Palmer
Substitutes: Ortega, Stones, Gundogan, Haaland, Rodri, Bernardo Silva, Charles, Robertson, Knight
Brentford team news
Team to play Man City: Raya; Hickey, Zanka, Pinnock, Mee, Henry; Oneyka, Janelt, Damsgaard; Mbeumo, Wissa
Substitutes: Strakhosa, Schade, Dasilva, Ghoddos, Ajer, Baptiste, Roerslev, Stevens, Trevitt