Brentford switch from a 4-3-3 to a 3-5-2 formation for the visit of Arsenal, as Zanka slots into the centre of defence alongside Nathan Collins and Ethan Pinnock.
Keane Lewis-Potter drops to the bench in place to facilitate the inclusion of the Dane, with Frank Onyeka starting in place of Mathias Jensen.
The Bees’ injury worries are perhaps best illustrated by the fact Thomas Strakosha and Ellery Balcombe – both goalkeepers – are included among the substitutes.
Arsenal boss Mikel Arteta has made extensive changes from the north London derby, with Aaron Ramsdale starting in goal in place of the rested David Raya and young winger Charles Sagoe Jr handed a debut.
Ben White, Gabriel Magalhaes and Eddie Nketiah are the only players to keep their places from the Spurs game, with Takehiro Tomiyasu, Jakub Kiwior, Jorginho, Kai Havertz, Emile Smith Rowe and Reiss Nelson the other players to start.
Their bench contains a mix of youth and experience and includes Gabriel Jesus, Martin Odegaard and Oleksandr Zinchenko.
Arsenal team news
Starting XI: Ramsdale, Tomiyasu, White, Gabriel, Kiwior, Jorginho, Havertz, Smith Rowe, Nelson, Sagoe Jr, Nketiah.
Subs: Hein, Cedric, Sweet, Walters, Zinchenko, Elneny, Odegaard, Cozier-Duberry, Jesus.
Brentford team news
Starting XI: Flekken, Roerslev, Collins, Zanka, Pinnock, Hickey, Norgaard, Janelt, Onyeka, Mbeumo, Wissa.
Subs: Strakosha, Balcombe, Jensen, Ghoddos, Ajer, Lewis-Potter, Yarmoliuk, Olakigbe, Brierley.