Inter Milan boss Simone Inzaghi has opted for Edin Dzeko over Romelu Lukaku up front alongside Lautaro Martinez.
The Belgian was hoping to get the nod having scored five goals in his last nine games for Inter, but he has to make do with a place on the bench.
Inter’s line-up also includes for Manchester United defender Matteo Darmian and former Arsenal and Manchester United playmaker Henrikh Mkhitaryan.
A big blow for hosts AC Milan as Rafael Leao misses out altogether.
The Rossoneri had been sweating on the fitness of the Portuguese winger after he came off injured early in their 2-0 win over Lazio at the weekend, and he has lost his race to recover in time.
Alexis Saelemakers starts in his place. Elsewhere, there’s a start for former Chelsea defender Fikayo Tomori, while Olivier Giroud leads the line.
Inter Milan team news
Team to play AC Milan: Onana, Darmian, Acerbi, Bastoni, Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco, Martinez, Dzeko.
Subs: Handanovic, Cordaz, Gagliardini, De Vrij, Gosens, Correa, Bellanova, Asllani, D’Ambrosio, Zanotti, Brozovic, Lukaku.
AC Milan team news
Team to play Inter Milan: Maignan, Calabria, Kjaer, Tomori, Hernandez, Krunic, Tonali, Bennacer, Saelemaekers, Diaz, Giroud.
Subs: Mirante, Nava, Ballo, Rebic, Kalulu, Origi, Thiaw, Junior Messias, Pobega, Gabbia, De Ketelaere.