Erik ten Hag makes three changes to the Man Utd team beaten by Brighton last time out, with Wout Weghorst handed a first start since the 2-0 loss to Newcastle on April 2 at the expense of Anthony Martial.
Christian Eriksen returns to the starting line-up in place of Fred and there’s a change at the back too, with Tyrell Malacia starting in place of Diogo Dalot, who drops to the bench.
Alejandro Garnacho is among the substitutes having recovered from injury. The 18-year-old has not featured since the goalless draw with Southampton on March 12.
Harry Maguire is also on the bench, with Victor Lindelof and Luke Shaw again preferred at centre-back.
Four changes from David Moyes. Declan Rice, Tomas Soucek and Nayef Aguerd all return to West Ham’s starting line-up after missing the 3-0 loss to Man City due to illness.
They replace Pablo Fornals, Flynn Downes and the injured Vladimir Coufal. Said Benrahma also starts, with Emerson the other player to drop to the bench.
Kurt Zouma remains absent due to injury.
West Ham team news
Team to face Man Utd: Fabianski, Kehrer, Aguerd, Ogbonna, Cresswell, Rice, Soucek, Bowen, Paqueta, Benrahma, Antonio.
Substitutes: Areola, Anang, Johnson, Fornals, Lanzini, Downes, Cornet, Ings, Emerson.
Man Utd team news
Team to face West Ham: De Gea, Wan-Bissaka, Lindelof, Shaw, Malacia, Casemiro, Eriksen, Antony, Fernandes, Rashford, Weghorst.
Substitutes: Butland, Maguire, Martial, Sabitzer, Fred, Dalot, Sancho, Williams, Garnacho.