The big Spurs team news is that Heung-Min Son has been dropped, with Richarlison starting in his place.
The South Korean has been out of form and starts the game on the bench, with Richarlison deservingly given a chance.
The Brazilian is one of three changes made by Spurs from the midweek Champions League defeat at AC Milan as Ben Davies comes in at left wing-back for Ivan Perisic, while Pierre-Emile Hojbjerg replaces Pape Sarr in central midfield to start alongside Oliver Skipp.
West Ham have made two changes to the side that drew 1-1 at home to Chelsea last weekend, with Tomas Soucek and Flynn Downes replacing Said Benrahma and the injured Lucas Paqueta.
There is good news for the Hammers on the bench, with Alphonse Areola (hamstring), Aaron Cresswell (illness) and Gianluca Scamacca (knee) all fit enough to take their places among the substitutes.
Tottenham team news – Richarlison starts ahead of Son
Team to play West Ham: Forster; Romero, Dier, Lenglet; Royal, Hojbjerg, Skipp, Davies; Richarlison, Kulusevski, Kane.
Subs: Austin, Sanchez, Son, Perisic, Danjuma, Porro, Tanganga, Moura, Sarr.
West Ham team news – Soucek and Downes start
Team to play Tottenham: Fabianski; Kehrer, Ogbonna, Aguerd; Coufal, Soucek, Rice, Downes, Emerson; Antonio, Bowen.
Subs: Areola, Johnson, Cresswell, Scamacca, Fornals, Lanzini, Ings, Benrahma, Casey.