Pep Guardiola makes four changes from the team which beat Wolves last time out in the league, including what looks like a new shape with Julian Alvarez partnering Erling Haaland in attack.
Bigger news even than that is Kevin De Bruyne is on the bench, with Bernardo Silva coming into midfield too.
Kyle Walker returns to the backline to captain the side while Aymeric Laporte is replaced by Nathan Ake.
Ilkay Gundogan and the injured John Stones are the other absentees, while Phil Foden – assessed ahead of the match – misses out on the squad.
It’s as you were for Spurs from the team that beat Fulham nearly a fortnight ago, meaning Pedro Porro won’t be featuring from the off this afternoon.
It also means Arnaut Danjuma’s second Premier League debut – if it does come today – will be from the bench.
Man City team news
Team to face Spurs: Ederson, Walker, Akanji, Ake, Lewis, Rodri, Silva, Grealish, Mahrez, Haaland, Alvarez.
Subs: Ortega, Dias, Phillips, Gundogan, Laporte, De Bruyne, Gomez, Perrone, Palmer.
Tottenham team news
Team to face Man City: Lloris, Emerson, Romero, Dier, Davies, Perisic, Hojbjerg, Bentancur, Kulusevski, Kane, Son.
Subs: Forster, Skipp, Sanchez, Richarlison, Danjuma, Sessegnon, Porro, Lenglet, Bissouma.