Pierre-Emile Hojbjerg makes his first Premier League start of the season for Tottenham, replacing the suspended Yves Bissouma.
Hojbjerg’s only other start of this campaign was also against Fulham as Spurs were knocked out of the Carabao Cup second round on penalties.
Heung-min Son and Cristian Romero have shaken off knocks picked up on international duty and are fit enough to start.
Brennan Johnson returns to the squad after recovering from injury. The 22-year-old had been out for nearly a month.
Calvin Bassey starts for Fulham for the first time in the Premier League since being sent off against Arsenal in August.
He has come in for injured centre-back Issa Diop.
Sasa Lukic is the only other change made by Marco Silva from their 3-1 win over Sheffield United. The midfielder replaces Alex Iwobi.
Carlos Vinicius starts up front again over Raul Jimenez.
Tottenham team news
Spurs: Vicario; Porro, Romero, Van de Ven, Udogie; Hojbjerg, Sarr; Kulusevski, Maddison, Richarlison; Son.
Subs: Forster, Skipp, Gil, Emerson, Dier, Lo Celso, Johnson, Phillips, Veliz.
Fulham team news
Fulham: Leno; Castagne, Bassey, Ream, Robinson; Palhinha, Lukic; Decordova-Reid, Pereira, Willian; Vinicius.
Subs: Rodak, Reed, Jimenez, Wilson, Cairney, Ballo-Toure, Muniz, Iwobi, De Fougerolles.