Antonio Conte makes three changes to the Tottenham side from the 1-0 win over Brighton in the Premier League.
Clement Lenglet, Emerson Royal and Richarlison return to the starting XI.
Lucas Moura is on the bench after returning from injury.
Ben Davies, Yves Bissouma and Matt Doherty all drop to the bench.
Tottenham XI: Lloris, Royal, Romero, Dier, Lenglet, Sessegnon, Bentancur, Hojbjerg, Richarlison, Son, Kane.
Subs: Forster, Spence, Doherty, Sanchez, Davies, Perisic, Skipp, White, Sarr, Bissouma, Bryan, Moura.
Eintracht Frankfurt XI: Trapp, Tuta, Hasebe, N’Dicka, Jakic, Rode, Sow, Lenz, Lindstrom, Kamada, Kolo Muani.
Subs: Grahl, Ramaj, Smolcic, Alidou, Borre, Alario, Chandler, Dina Ebimbe, Gotze.