Pep Guardiola has made nine changes to Manchester City’s side with Kalvin Phillips, Micah Hamilton and Oscar Bobb all starting.
Hamilton, 20, is set to make his first-team debut while this is Bobb’s first-ever City start and Phillips’ first in the Champions League.
Kyle Walker, Ruben Dias, Josko Gvardiol, Rodri, Bernardo Silva, Julian Alvarez, Nathan Ake and Phil Foden all drop to the bench following the 2-1 win over Luton.
Ederson did not travel along with the injured Erling Haaland, Jeremy Doku and Kevin De Bruyne.
Mateo Kovacic and Jack Grealish are the only two to keep their place from Saturday’s victory.
Red Star team news
Red Star Belgrade: Glazer, Nedeljkovic, Spajic, Dragovic, Djiga, Mijailovic, Hwang, Bukari, Kanga, Ndiaye, Olayinka.
Subs: Vasiljevic, Degenek, Katai, Mijatovic, Krasso, Milunovic, Stamenic, Kangwa, Rodic, Lucic, Kabic, Mitrovic.
Man City team news
Man City: Ortega, Lewis, Stones, Akanji, Gomez, Phillips, Kovacic, Nunes, Bobb, Grealish, Hamilton.
Subs: Carson, Grant, Walker, Dias, Ake, Rodrigo, Alvarez, Bernardo, Gvardiol, Foden, Alleyne, Susoho.